GENERAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (4) : 4-WEEK REPEATED DOSE INTRAVENOUS TOXICITY STUDY FOLLOWED BY 4-WEEK RECOVERY PERIOD IN DOGS
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چکیده
منابع مشابه
A 4-week Repeated Dose Toxicity Study of Glycine in Rats by Gavage Administration
In order to examine the toxicity profile of glycine, an authorized food additive, a solution of glycine in water for injection was administered orally (via gavage) to male SD rats (Crl:CD(SD)) once daily for 4 weeks at doses of 500, 1000 and 2000 mg/kg/day in a volume of 10 mL/kg. Control animals received vehicle only. No animals died, and no glycine-related changes were observed in body weight...
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Traditional herbal medicines have been used for centuries in Asian countries. However, recent studies have led to increasing concerns about the safety and toxicity of herbal prescriptions. Bojungikgi-tang (BJIGT), a herbal decoction, has been used in Korea to improve physical strength. To establish the safety information, BJIGT water extract was evaluated in a 4-week repeated-dose oral toxicity...
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The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male rats at dose levels of 0, 100, 300, and 1,000 mg/kg/day for 4 weeks. All rats were sacrificed at the end of the treatment period. During the test period, clinical signs, mortality, body weight, ...
متن کاملA 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test
OBJECTIVES In this study, we investigated the 4-week repeated-dose oral toxicity of gami-jakyak gamcho buja decoction (Mecasin) to develop safe treatments. METHODS In order to investigate the 4-week oral toxicity of Mecasin, we administered Mecasin orally to rats. Sprague-Dawley (SD) rats were divided into four groups of five male and five female animals per group: group 1 being the control g...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1999
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.24.supplementi_41